Apoptosis-, proliferation, immune function-, and drug resistance- related genes in ER positive, HER2 positive and triple negative breast cancer
نویسندگان
چکیده
منابع مشابه
Mammographic findings in different breast cancer subtypes (luminal, Her2 positive, triple negative)
Background: Prognosis and management of breast cancer are defined by different variables including histological type, grading, clinical stage, Her2+, estrogen and progesterone receptor conditions. Generally, mammography is one of the most important imaging which is done in breast cancer patients. The aim of this research was to evaluate different mammographic patterns in different breast cancer...
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Breast cancer patients have different responses to chemotherapeutic treatments. Genes associated with drug response can provide insight to understand the mechanisms of drug resistance, identify promising therapeutic opportunities, and facilitate personalized treatment. Estrogen receptor (ER) positive and ER negative breast cancer have distinct clinical behavior and molecular properties. However...
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The relation between estrogen receptors (ER) and argyrophilic nucleolar organizer regions (AgNORs) in situ within human breast cancer cells was analyzed. For AgNOR measurements in 49 invasive breast carcinomas, a new reproducible staining method for dual demonstration of ER and AgNORs was applied. Quantitative AgNOR variables were determined in ER-positive and ER-negative tumor cells by digital...
متن کاملApoptosis/Necrosis Induction by Ultraviolet, in ER Positive and ER Negative Breast Cancer Cell Lines
BACKGROUND Ultraviolet (UV) light exposure has been one of the major inducers of apoptosis. UV exposure has caused pyrimidine dimers and DNA fragmentation which might lead to cell cycle arrest and apoptosis signals activation. UV induced apoptosis has investigated in MDA-MB 468 as an ER negative breast adenocarcinoma and MCF-7 as an ER positive breast cancer cell line. Apoptosis induction rate ...
متن کاملStandard therapy of HER2-positive and triple negative metastatic breast cancer – present and future
TREATMENT OF HER2-POSITIVE METASTATIC BREAST CANCER The treatment of HER2-positive metastatic breast cancer (MBC) has been improved. The HER family consists of four transmembrane receptors that mediate in a complex network of signaling pathways (1). HER1, HER2, and HER3 are all implicated in the development and progression of cancer (2, 3). The HER1 and HER2 receptors are perhaps the best known...
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ژورنال
عنوان ژورنال: Neoplasma
سال: 2012
ISSN: 1338-4317
DOI: 10.4149/neo_2012_055